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Whereas minimal-rely MBL seldom progresses to CLL, higher-count MBL progresses to CLL demanding therapy at a price of 1% to 2% annually. Significant-count MBL is distinguished from Rai 0 CLL determined by whether the B-cell rely is earlier mentioned or down below five × 109/L. Whilst persons with both of those large-count MBL and CLL Rai stage 0 a